By Paul M. Wassarman (Eds.)

ISBN-10: 1559383488

ISBN-13: 9781559383486

The inaugural quantity of Advances in Developmental Biology and Biochemistry paints a slightly large stroke throughout the box. trend formation and mobile verbal exchange in the course of animal improvement, in addition to Y chromosome functionality in the course of mammalian improvement, are significant issues of this quantity. a number of experimental structures, together with mice, flies, and worms are thought of.

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28:10&115. Eicher. E. M.. Phillips, S. J.. and Washburn. L. L. (1983) The use of molecular probes and chromosomal rearrangements to partition the mouse Y chromosome into functional regions. In: Recombinant DNA and Medical Genetics. (Messer. A,. and Porter. H.. ). pp. 57-71. Academic Press. New York. Eicher. E. M . and Washburn. L. L. (1983) Inherited sex reversal in mice: Identification of a new primary sexdetermining gene. 1. Exp. Zml. 228:297-304. Eicher. E. M.. and Washburn. L. L. (1986) Genetic control of primary sex determination in mice.

1986; Rijsewijk et al.. , 1987a). In vivo, mammary tumors develop in transgenic mice injected with an MMTV-Wnr-I construct that essentially mimics a naturally occurring viral integration site cloned from an MMTVinduced mammary tumor (Tsukamoto et al.. 1988). A long latency is associated with tumor formation in these transgenic mice, indicating that deregulated Wnr-I expression alone is not sufficient for cellular transformation. Interestingly. in male transgenic mice, mammary hyperplasia results, suggesting that Wnr- I can overcome the testosterone-induced regression of mammary gland development (Sakakura, 1987).

And Kato, Y. (1990) Germ cell deficiency causes testis cord differentiation in reconstituted mouse fetal ovaries. 1. Exp. Zool. 253:6 1-70, Hayward. P.. and Shire. J. G . M. (1974) Y chromosome effect on adult testis size. Nature (London) 250449-500. Herrick. C. S.. and Wolfe. H. G . (1977) Effect of the Y chromosome on testis size in the mouse (Mus musrulus). Genetics 86~27. Hunt. , and Mittwoch. U. (1987) Ychromosomal and other factors in the development of testis size in mice. Genet. Res. Camb.

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A Research Annual by Paul M. Wassarman (Eds.)


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